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Cover of A Critical Inquiry into Functional Precision Oncology and Rare Pharmacogenomic Variants
Pharmacogenomics and Precision MedicineMedicine & Health

A Critical Inquiry into Functional Precision Oncology and Rare Pharmacogenomic Variants

By Eleanor M. Whitfield

Can a tumor be exquisitely sensitive to a drug in the laboratory while the patient carrying it remains unable to benefit safely? Rare pharmacogenomic variants make that question more than hypothetical. In this research monograph, Eleanor M. Whitfield examines the uneasy meeting between functional precision oncology and uncommon genetic variation that may change how drugs are handled by the body. From patient-derived organoids and single-cell screens to enzyme assays, exposure-response analysis and independent clinical validation, the book reconstructs the evidence required to distinguish genuine therapeutic insight from convincing laboratory appearance. A worked, explicitly illustrative two-axis inquiry shows how tumor susceptibility and host pharmacology can support, contradict or fail to resolve one another. Twelve chapters address assay fidelity, rare-variant interpretation, safety, prospective study design and the limits of prediction. Written for advanced students, biomedical researchers and specialist professionals, the book offers a rigorous framework for asking what precision oncology can presently establish—and exactly where further evidence is needed.

PublisherLighthouse Books, Delaware, USA
Universal Book ID45257
SubjectFunctional Precision Oncology in Rare Pharmacogenomic Variants
DisciplineMedicine & Health
eISBN9781398285095
Publication TypeMonograph
Available formatsPDF
Publication Date2026-11-09
LanguageEnglish
Pages137
CategoryPharmaceutical science research monograph
Tagsfunctional precision oncology research, rare pharmacogenomic variants, patient derived organoid drug screening, DPYD and fluoropyrimidine pharmacogenetics
List Price$8.00 USD

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Table of Contents

Introduction — A Critical Inquiry into Functional Precision Oncology and Rare Pharmacogenomic Variants
1. Functional Precision Oncology: The Specific Problem of Rare Pharmacogenomic Variants
2. Rare Pharmacogenomic Variants: Scope, Vocabulary, and Necessary Background
3. What Counts as Evidence about Functional Precision Oncology in Rare Pharmacogenomic Variants
4. Therapeutic or product rationale for Functional Precision Oncology
5. Relevant biological and material properties in Rare Pharmacogenomic Variants
6. Functional Precision Oncology: Experimental platforms under the Conditions of Rare Pharmacogenomic Variants
7. Rare Pharmacogenomic Variants: Exposure and response relationships for the Study of Functional Precision Oncology
8. Sources of product or population variation: A Worked Inquiry into Functional Precision Oncology in Rare Pharmacogenomic Variants
9. Safety and translational limitations: Distinguishing Claims about Functional Precision Oncology
10. Independent analytical validation: Checking Conclusions in Rare Pharmacogenomic Variants
11. Development evidence requirements: What the Analysis Establishes about Functional Precision Oncology in Rare Pharmacogenomic Variants
12. Unanswered Questions at the Intersection of Functional Precision Oncology and Rare Pharmacogenomic Variants
Conclusion — Findings, Boundaries, and Further Inquiry
References and Further Reading
Glossary or Notation Guide
Index

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